The following page provides scientific publications that utilize the bundlemer technology. Bundlemers represent a unique and tunable monodispersed peptide-based particle that can be used as a molecular building block for hierarchical material design. To learn more about how bundlemers have been designed and used for various applications, check out the articles below. The order in which articles are presented represents the order in which they were published.
Computationally Designed Peptides for Self-Assembly of Nanostructured Lattices
Huixi Violet Zhang, Frank Polzer, Michael J. Haider, Yu Tian, Jose A. Villegas, Kristi L. Kiick, Darrin J. Pochan, Jeffrey G. Saven
Sci. Adv., 9 (2016).
Transition from Disordered Aggregates to Ordered Lattices: Kinetic Control of the Assembly of a Computationally Designed Peptide
Yu Tian, Huixi Violet Zhang, Kristi L. Kiick, , Jeffrey G. Saven, Darrin J. Pochan
Org. Biomol. Chem., 15 6109-6118 (2017).
DOI: 10.1039/C7OB01197K
Self-Assembly and Soluble Aggregate Behavior of Computationally Designed Coiled-Coil Peptide Bundles
Michael J. Haider, Huixi Violet Zhang, Nairiti Sinha, Jeffrey A. Fagan, Kristi L. Kiick, Jeffrey G. Saven, Darrin J. Pochan
J. Soft Matter, 14 5488-5496 (2018).
DOI: 10.1039/C8SM00435H
Nanotubes, Plates, and Needles: Pathway-Dependent Self-Assembly of Computationally Designed Peptides
Yu Tian, Frank B. Polzer, Huixi Violet Zhang, Kristi L. Kiick, Jeffrey G. Saven, Darrin J. Pochan
Biomacromolecules, 19 4286-4298 (2018).
Polymers with Controlled Assembly and Rigidity Made with Click-Functional Peptide Bundles
Dongdong Wu, Nairiti Sinha, Jeeyoung Lee, Bryan P. Sutherland, Nicole I. Halasynski, Yu Tian, Jeffrey Caplan, Huixi Violet Zhang, Jeffrey G. Saven, Christopher J. Kloxin, Darrin J. Pochan
Nature, 574 658-662 (2019).
DOI: s41586-019-1683-4
Polyelectrolyte Character of Rigid Rod Peptide Bundlemer Chains Constructed via Hierarchical Self-Assembly
Nairiti Sinha, Dongdong Wu, Christopher J. Kloxin, Jeffrey G. Saven, Grethe V. Jensen, Darrin J. Pochan
Soft Matter, 15 9858-8670 (2019).
DOI: 10.1039/C9SM01894H
Recombinant Expression of Computationally Designed Peptide-Bundlemers in Escherichia coli
Nairiti Sinha, Christopher J. Kloxin, Jeffrey G. Saven, Grethe V. Jensen, Zvi Kelman, Darrin J. Pochan
J. Biotech., 330 57-60 (2021).
Intramolecular Structure and Dynamics in Computationally Designed Peptide-Based Polymers Displaying Tunable Chain Stiffness
Nairiti Sinha, Yi Shi, Yao Tang, Christopher J. Kloxin, Jeffrey G. Saven, Antonio Faraone, Grethe V. Jensen, Darrin J. Pochan
Phys. Rev. Mater., 5 (2021).
Colloid-Like Solution Behavior of Computationally Designed Coiled Coil Bundlemers
Nairiti Sinha, Rui Guo, Rajkumar Misra, Jeffrey Fagan, Antonio Faraone, Christopher J. Kloxin, Jeffrey G. Saven, Grethe V. Jensen, Darrin J. Pochan
J. Colloid Interface Sci., 606 1974-1982 (2022).
Computational Design of Homotetrameric Peptide Bundle Variants Spanning a Wide Range of Charge States
Rui Guo, Nairiti, Sinha, Rajkumar Misra, Yao Tang, Matthew Langenstein, Kyunghee Kim, Jeffrey Fagan, Christopher J. Kloxin, Grethe V. Jensen, Darrin J. Pochan, Jeffrey G. Saven
Biomacromolecules, 23 1652-1661 (2022).
Genetic Fusion of Thermoresponsive Polypeptides with UCST-type Behavior Mediates 1D Assembly of Coiled-Coil Bundlemers
Sai S. Patkar, Yao Tang, Arriana M. Bisram, Tianren Zhang, Jeffrey G. Saven, Darrin J. Pochan, Kristi L. Kiick
Angew. Chem. Int. Ed., 62 (2023).
Bottom–Up On-Surface Synthesis Based on Click-Functionalized Peptide Bundles
Yanmei He, Dongdong Wu, Xinigdong, Zhang
Nanoscale, 15 8996-9002 (2023).
DOI: 10.1039/D3NR01070H
Impact of Peptide Length and Solution Conditions on Tetrameric Coiled Coil Formation
Joshua E. Meisenhelter, Nolan R. Petrich, Jacquelyn E. Blum, Albree R. Weisen, Rui Guo, Jeffrey G. Saven, Darrin J. Pochan, Christopher J. Kloxin
Biomacromolecules, (2024).
